Acute coronary syndrome accompanying mast cell activation from allergic, hypersensitivity, or anaphylactoid reactions was first described by kounis and zavras in 1991 and has been referred to as allergic angina or allergic myocardial infarction 1, 2. The treatment of kounis syndrome consists of managing the hypersensitivity reaction and specifically treating the coronary spasm or occlusion. Kounis syndrome was described in 1991 by kounis and zavras as the coincidental occurrence of acute coronary syndromes with allergic reactions anaphylactic. Rico cepeda p, palencia herrejon e, rodriguez aguirregabiria m. Pdf kounis syndrome is an acute coronary syndrome in the context of a hypersensitivity reaction. Kounis syndrome was described in 1991 by kounis and zavras as the.
Kounis syndrome ks was described in 1991 by kounis and zavras as the coincidental occurrence of acute coronary syndromes acss with allergic reactions anaphylactic or anaphylactoid. Presenta como antecedentes hipertension arterial hta, obesidad y tabaquismo. Kounis n, mazarakis a, tsigkas g, giannopoulos s, goudevenos j. This syndrome is infrequent, and is not well known. Espasmo coronario secundario a reaccion alergica o sindrome.
The main pathophysiological mechanism appears to be coronary vasospasm. Coronary spasm secondary to an allergic reaction or kounis syndrome. Allergic myocardial ischemia secondary to ibuprofen. Em 1991, kounis e zavras descreveram pela primeira vez a sindrome da angina alergica e o infarto do miocardio alergico, atualmente conhecido como. Kounis syndrome is defined as acute coronary syndrome symptoms such as chest pain relating to reduced blood flow to the heart caused by an allergic reaction or a strong immune reaction to a drug or other substance. Acude a urgencias por dolor abdominal en fosa iliaca derecha y fiebre. Kounis syndrome was described in 1991 by kounis and zavras as the coincidental occurrence of acute coronary syndromes with allergic reactions anaphylactic or anaphylactoid. Christian dauvergne 1,2, mario araya 1,2, alejandro abufhele 1.
The acs was probably due to a hypersensitivity reaction. Kounis syndrome is an acute coronary syndrome in the context of a hypersensitivity reaction. Es conocido tambien como sindrome anginoso alergico. Allergic myocardial ischemia secondary to ibuprofen, kounis syndrome. In acute coronary syndrome acs, coronary angiography excludes significant coronary disease in 520% of cases. Kounis syndrome has been established as a hypersensitivity coronary disorder induced by various conditions, drugs, environmental exposures, foods and coronary stents. In consequence, it is usually misdiagnosed leading to inappropriate treatment. Kounis syndrome corresponds to the occurrence of myocardial injury following an allergic insult. Kounis syndrome medicina intensiva english edition. The current literature is limited to case studies and there are no international recommendations concerning this topic.
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